Gray and Gills (2016) view South-south cooperation (SSC) as an organising concept and a set of practices in pursuit of historical changes through a vision of mutual benefit and solidarity among the disadvantaged of the world system. From this perspective, SSC has become increasingly important as a means for countries within the global south axis to share knowledge, experience, know-how and solutions. In forging these interactions between South-South countries, "horizontality" is pivotal for conveying ideas of trust, mutual benefit and equity among cooperating countries. There has been a longstanding relationship between Africa and the Caribbean, with the two regions historically collaborating in areas of mutual interest at the bilateral, regional and multilateral levels. This partnership has been renewed over time in keeping with changes in the global political economy. However, while these states continue to cooperate in multiple fora in relation to different issues, economic activity and trade between them remain negligible. This paper argues that there is potential to enhance integration between these two regions by mainstreaming trade relations through a deliberate effort by related governments via SSC.